Session Descriptions

Sunday June 2
John Moulds Memorial Lecture
Provision of Blood for the Highly Immunized Patient,  Sandra Nance, MS, MT(ASCP)SBB  
The lecture will focus on the need for appropriate resolution of complex serologic cases, using all the tools in the immunohematologists toolbox, the inclusion of a personalized medicine approach to these cases. Concepts regarding RHCE allele selected products and testing with monocyte monolayer assays will be discussed. The provision of rare blood through the American Rare Donor Program and requirements for information for international requests are important to understand when rare blood is needed.
Sunday June 2

Thalassemia – Alloimmunization & Antigen Matching Practices
Clinical Care and RBC Alloimmunization for Thalassemia Patients, Zora Rogers, MD
This will be a brief introduction to the clinical management of persons, particularly children, with Thalassemia focusing on the use of RBC transfusion. 

Matching Practices for Thalassemia - Blood Center Perspective, Samantha Ngamsuntikul (Gomez), MD

Sunday June 2

Hemoglobinopathies: The Best and the Worst
BMTs in sickle and Thalassemia patients Victor Aquino, MD
The presentation will review the process and indications for bone marrow transplantation in children with sickle cell anemia and thalassemia

Hyperhemolysis in Sickle Cell Disease, Eric Gehrie, MD

One of the most feared complications of transfusion in the sickle cell disease population is hyperhemolysis (also known as bystander hemolysis), which is the phenomenon where a patient red blood cells are destroyed as a result of transfusion. In this case-based exercise, Dr. Gehrie will explain how to recognize this important transfusion complication, and what the laboratory should be prepared to provide to affected patients.

Sunday June 2
Nuts and Bolts: Reimbursement &  AABB IRL Standards Changes
CMS Reimbursement for Genotyping, Suzanne Butch, MLS(ASCP)SBB, DLM
This session will review the billing process and codes used in billing for genotyping laboratory testing. A process for investigating denied claims will be discussed. 

I Fought Law, Monica Kalvelage, MS, MT(ASCP)MB, SBB 
This session is designed to review common citations issued by AABB and CAP, best behavior during an audit, and to recap changes made to the Standards, 10th edition for IRL.

Sunday June 2
Roundtable Discussions & Blood Bank Trivia
Blood Bank Trivia, Phyllis Haines, MLS(ASCP)CM SBB
Blood Bank Jeopardy

Monday June 3

Blood Group Antigens and their Expression
Modifiers of Red Cell Antigen Expression: Margaret Keller, PhD
There are cases where a patient or donor red cells lack an antigen or antigens, yet the gene encoding those antigens is found to be intact and without deleterious mutation. This talks aims to show how deletions or mutations elsewhere in the genome can impact antigen expression and how molecular methods can aid in determining the phenotype and blood needs.

Blood Group Review- Kidd System, Janis Hamilton​, MS, MT(ASCP)SBB
The Kidd blood group system has long been recognized as clinically important in transfusion medicine. Anti-Jka, anti-Jkb and anti-JK3 are well known for their ability to hemolyze-antigen positive red cells, even when the antibody is not detectable. DNA analysis has revealed new information about the system. Discrepancies in serological and molecular JK results, variation in JK antigen status using different reagents and apparent alloantibody in antigen-positive individuals are now often explainable. This presentation will summarize current information on Kidd system alleles, antigens and antibodies, including new findings on the molecular basis of the In(JK) null phenotype.
Monday June 3
Big C Discrepancies & Drug Interference 
C Typing Discrepancies - Genotype vs Phenotype, Trina Horn, MS, MLT(ASCP)SBB
This presentation will describe typing discrepancies involving the big C antigen in both the patient and donor populations. The molecular characteristics of the RHD and RHCE genes will be discussed and variants that may cause C typing discrepancies will be outlined. Through several case studies, the audience will experience different scenarios where the C antigen type was discordant and how molecular testing can help resolve such issues.

Attack of the Clonals: How to Deal with Anti-CD38 and Anti-CD47 Interference,  Chris Lough, MD 
The rising use of monoclonal antibody therapy in patients with hematologic, and likely soon solid, malignancies has caused much consternation amongst immunohematology laboratories through interference with common testing methods. In this presentation we will review current practices available for dealing with interference secondary to anti-CD38 therapy, as well as discuss options for handling the newer monoclonal anti-CD47 agents currently in clinical trials. Case studies will be presented to illustrate approaches to workups in these patient populations. ​

Monday June 3
Case Studies
Case Study#1:  Antibody to an Antigen of High Prevalence: A Voyage into Choppy Waters, Kristin Vail, MLS(ASCP)CM SBBCM
Presentation of case studies that involve the methods and procedures utilized in the identification of an antibody of high prevalence. Discussion of subsequent testing and the transfusion management options in such cases. 

Case Study #2, Phyllis Haines, MLS(ASCP)CM SBB
Identifying a Rh discrepancy on an donor with historical ABO/Rh on record. 

Case Study #3, Brett Dunlap, MS, MLS(ASCP)
A case sent for complex antibody identification, resulting in an antibody to a high incidence antigen and another underlying allo-antibody.